Landmarks – Vorotynsk http://vorotynsk.com/ Fri, 14 Jan 2022 06:38:02 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://vorotynsk.com/wp-content/uploads/2021/06/icon-150x150.png Landmarks – Vorotynsk http://vorotynsk.com/ 32 32 Rebecca Smith: Let’s use the planning system to achieve better and more sustainable monuments https://vorotynsk.com/2022/01/14/rebecca-smith-lets-use-the-planning-system-to-achieve-better-and-more-sustainable-monuments/ Fri, 14 Jan 2022 06:14:30 +0000 https://vorotynsk.com/2022/01/14/rebecca-smith-lets-use-the-planning-system-to-achieve-better-and-more-sustainable-monuments/ Cllr Rebecca Smith is Chair of Plymouth City Council’s Planning Committee. She was a candidate for Plymouth Sutton and Devonport in the last general election. Last May, the Tories unexpectedly took control of Plymouth City Council. Therefore, having served on the planning committee since my election in 2018, I was appointed as chair. And I […]]]>

Cllr Rebecca Smith is Chair of Plymouth City Council’s Planning Committee. She was a candidate for Plymouth Sutton and Devonport in the last general election.

Last May, the Tories unexpectedly took control of Plymouth City Council. Therefore, having served on the planning committee since my election in 2018, I was appointed as chair. And I wanted to stir things up a bit…

My biggest frustration as a member of the Committee has been when major landmark developments in key locations in the city have come before us for decision. If questions arose about the design and aesthetics (often in my opinion lacking in ambition and/or beauty), we were systematically told that it was too late to make any changes.

I remember a project in one of the most spectacular places in the city. When he came to the Committee, he prompted a series of questions about his design. Again we were told there was nothing we could do about it. With hindsight and experience, I now know that this is not strictly true, but when development is carried out by a large landowner and costs huge sums of money, the implication has always been that the cost for the developer and the embarrassment for the planning department was too high to justify a change at the last stage of the planning committee. However, being part of a decision-making process to validate (sometimes) ugly buildings in the city is not the reason why I joined the planning committee, let alone chair it.

Plymouth City Council, like many others, declared a climate emergency in March 2019. Using the planning committee as a vehicle to help the city mitigate this was also a priority for me. I wanted to make sure that the Committee could continue to push for development to be as environmentally sustainable as possible.

Plymouth have the potential to change administration again in May 2022. I knew I only had a year to turn things around. To see building permits granted for flagship and strategic projects that are more ambitious in design quality and form, push the boundaries of what is possible in terms of the environment and sustainability, and improve amenities for the local community.

The question was how to achieve this.

Plymouth has an award-winning planning service. We also have shiny, beautiful and cutting-edge buildings – the Roland Lewinsky Building, The Box, The Sherwell Center to name a few. Indeed, before Christmas, I attended the triennial awards ceremony to celebrate the city’s exciting design and development – the Abercrombie Awards. However, I firmly believed that we could raise the bar of ambition even higher.

Following my appointment as Chairman, every conversation I had with a senior council official, including the Managing Director, included my desire to see excellent, ambitious design and environmental sustainability at the heart of building permits. . I wanted developers to be held accountable when they put forward their plans for the city. And I finally found the person who could help me deliver that.

In talking with colleagues across the country, I knew that some councils have the opportunity for councilors to comment on projects before they come to the committee. Speaking to our service manager it turned out that we had a mechanism in the board constitution to do this and with guidance on how to do this set out in the planning committee code of practice we were ready to go.

Let me introduce you to our pre-member briefings.

Granted, it’s not the most exciting name, but they do what it says on the box. At least quarterly, all members of the Board are invited to a meeting during which important or significant developments are presented at the pre-application stage, followed by a question-and-answer session with the developer. While committee members should be particularly careful not to pre-determine an application, the principle of the process is to provide the developer and applicant with an idea of ​​how the city views their proposal and, hopefully, their show where they might want to improve and improve elements relating to design, sustainability and public equipment, before a formal request is made. It provides planning officers with support when working with applicants. It also allows for member engagement at the pre-application stage where the final application may not be determined by the planning committee.

During our first session in the fall, two developments were presented to us: a new business park in the north of the city and a new eye hospital. Following strong questions about why a building big enough to house two supermarkets didn’t have solar panels on the roof – a big omission as far as councilors are concerned – the developer said he would walk away and would consider how he might be able to incorporate them. Exactly the kind of response I had hoped the meeting would get. We also asked about how the eye hospital could be as tactile as possible while still being ambitious enough with its public spaces given that it is likely to be a feature of the city for up to a century.

None of these issues were pre-determining, but rather sought to scrutinize the developers’ plans and elevate the game for the benefit of the city, the environment and the adults, children and young people who live, work or visit Plymouth.

I hope that through the mechanism of four simple, but timely, meetings a year, Plymouth will benefit from a new generation of iconic buildings that are exceptional in design, cutting edge in sustainability and provide a valuable public good. Towards the city.

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Syrian torture victims await justice in landmark German trial https://vorotynsk.com/2022/01/12/syrian-torture-victims-await-justice-in-landmark-german-trial/ Wed, 12 Jan 2022 09:52:39 +0000 https://vorotynsk.com/2022/01/12/syrian-torture-victims-await-justice-in-landmark-german-trial/ BERLIN (AP) – Victims of torture in Syria and human rights activists hope the upcoming verdict in a landmark trial will be a first step towards justice for countless Syrians who have suffered abuse at the hands of the president’s government Bashar Assad during the long run of the country. ongoing conflict. A court in […]]]>

BERLIN (AP) – Victims of torture in Syria and human rights activists hope the upcoming verdict in a landmark trial will be a first step towards justice for countless Syrians who have suffered abuse at the hands of the president’s government Bashar Assad during the long run of the country. ongoing conflict.

A court in the German city of Koblenz is due to render its ruling on Thursday in the trial of Anwar Raslan, a former Syrian secret police officer accused of crimes against humanity for overseeing the mistreatment of detainees in a nearby prison from Damascus ten years ago.

Speaking this week ahead of the verdict, one of those who testified against Raslan said that whatever the outcome, court proceedings in Germany would send an important message that those responsible for crimes in Syria may be required to return. accounts.

“As Syrians who suffered a lot, especially after the start of the revolution, (the trial shows) this suffering is not in vain,” said Wassim Mukdad, a torture survivor and co-complainant who – like the accused – now lives in Germany.

Mukdad was among dozens of witnesses who testified against Raslan and a second defendant, Eyad al-Gharib, who was convicted last year of aiding and abetting crimes against humanity and sentenced by Koblenz State Court to 4 and a half years in prison.

The court found that al-Gharib was part of a unit that held anti-government protesters and took them to a center in the Syrian city of Douma known as Al Khatib, or Branch 251, where they were tortured.

Syrian Wassim Mukdad poses for a photo at the Berlin office of the European Center for Constitutional and Human Rights, Germany (AP Photo / Frank Jordans, file)

Federal prosecutors allege that Raslan was the senior officer in charge of the prison and oversaw the “systematic and brutal torture” of more than 4,000 prisoners between April 2011 and September 2012, resulting in the deaths of at least 58 people.

The court heard evidence implicating Raslan in 30 of the deaths, said Patrick Kroker, an attorney with the European Center for Constitutional and Human Rights who represented several survivors at the trial. Cases of sexual violence are also considered part of the charge, he said.

If found guilty, Raslan could be sentenced to life in prison. His lawyers last week asked the court to acquit their client, saying he had not personally tortured anyone and that he defected in late 2012.

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Kaide Gordon offers glimpse into Liverpool’s bright future with historic goal https://vorotynsk.com/2022/01/10/kaide-gordon-offers-glimpse-into-liverpools-bright-future-with-historic-goal/ Mon, 10 Jan 2022 09:22:38 +0000 https://vorotynsk.com/2022/01/10/kaide-gordon-offers-glimpse-into-liverpools-bright-future-with-historic-goal/ Kaide Gordon scored against Shrewsbury Town at Anfield (AFP via Getty Images) For a brief period on Sunday, Kaide Gordon’s Wikipedia entry included the phrase: “He is widely regarded as the greatest footballer of all time.” It might be a bit more difficult for a player with a lonely senior goal, who came against a […]]]>

Kaide Gordon scored against Shrewsbury Town at Anfield (AFP via Getty Images)

For a brief period on Sunday, Kaide Gordon’s Wikipedia entry included the phrase: “He is widely regarded as the greatest footballer of all time.” It might be a bit more difficult for a player with a lonely senior goal, who came against a side from Shrewsbury in the bottom half of League One, but youngsters can inspire excitement. The promise of potential offers a feeling of limitless possibility. Sometimes it can even be a first glimpse of greatness.

Gordon’s page was quickly reduced to the most factual details: He was 17 years and 96 days old when he scored and only one man (or boy, really) had knocked for a hugely decorated club at an earlier age. “The second youngest goalscorer for Liverpool, which is absolutely exceptional,” said Jurgen Klopp. Especially considering the parade of young talents passing through Anfield. Gordon is a younger scorer than Robbie Fowler and Michael Owen, Steven Gerrard and Trent Alexander-Arnold, Raheem Sterling and Steve McManaman.

But he’s older than Ben Woodburn, the tale uplifting. Liverpool scorer at 17, loaned to Hearts at 22 after disappointing stints at Sheffield United, Oxford and Blackpool, the Welshman is a case of development stopped. He was the future once. Now that mantle has passed to Gordon, who may not be flash in the pan.

There’s a lot to suggest that he has a better chance at ending his career more than just a statistical footnote. Conor Bradley, an 18-year veteran, groomed Gordon for his historic goal and Klopp said: “They are real talent.” Gordon can be a direct dribbler with a habit of shooting from the infield. He mastered the most difficult skill first.

“It’s Kaide,” Klopp said. “When he’s in these situations he’s really calm. I’m not saying he will always score in these situations the rest of his career, but I’m pretty sure more often than not because it’s just him. When a cross arrives from the left side, she will find it in the box. He has a nose for that. The predatory instincts are allying with accuracy; an earlier shot, aimed at the near post, showed a similar intention to aim for the corners of the goal.

“His finish is exceptional but everything else is still a kid,” Klopp said. “So in playing the position he’s playing there’s so much to improve on.” For his goal, he showed the presence of mind to touch with the right foot before finishing with the left. There is an obvious model at Anfield for such a finisher and it seemed Salah-esque. That Gordon is a quick and clinical Klopp-type player, a reverse winger with a penchant for finishing, should serve him well.

That he has a manager who can trust the youth and think long-term, who didn’t buy a right-back when he was waiting for Alexander-Arnold to develop and who, until the cruel intervention of the injury, perhaps installed Harvey Elliott as a top pick this season, gives him a shot. It would be premature to name him Salah’s successor but, 13 years his junior, he may be closer to his prime when the Egyptian begins to decline.

It was a sign of character he scored when Liverpool, behind Shrewsbury, needed it. “It’s really not easy to show up in a game like this and he did it,” Klopp said. But he’s otherwise largely a work in progress, as his manager’s analysis has clearly shown.

“There is a long way to go, no problem,” he said. “Kaide has time and we’ll give it to him. He will have his minutes here and there. Those last three words made a marked difference to his verdict on the new Takumi Minamino. “We desperately need him,” he said of a more experienced striker who will likely replace Salah and Sadio Mane next month.

Minamino may be the near future, childish little Gordon being the subject of dreams in the late 2020s and 2030s. He’s so young he was born when Rafa Benitez was Liverpool manager, just three months old. before Steve Cotterill’s Burnley knocked them out of the FA Cup, thanks to Djimi Traore’s comedic goal. Seventeen years later, the end of the game against another Cotterill team was more intentional, thanks to Roberto Firmino.

A match decorated by its goal may end up being defined by Gordon’s, whether its eventual fate is closer to that of Woodburn or Owen.


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UK hits grim milestone of 150,000 Covid deaths https://vorotynsk.com/2022/01/08/uk-hits-grim-milestone-of-150000-covid-deaths/ Sat, 08 Jan 2022 17:31:34 +0000 https://vorotynsk.com/2022/01/08/uk-hits-grim-milestone-of-150000-covid-deaths/ T he UK has reached a grim milestone recording more than 150,000 Covid deaths. Official government figures today revealed that another 313 people had died within 28 days of testing positive for Covid-19, bringing the total number of deaths to 150,057. The UK is the seventh country to exceed 150,000 reported deaths, after the US, […]]]>
T

he UK has reached a grim milestone recording more than 150,000 Covid deaths.

Official government figures today revealed that another 313 people had died within 28 days of testing positive for Covid-19, bringing the total number of deaths to 150,057.

The UK is the seventh country to exceed 150,000 reported deaths, after the US, Brazil, India, Russia, Mexico and Peru.

In a statement, the Department of Health and Social Affairs (DHSC) said on Saturday: “Every death from this virus is a tragedy and our sympathies go out to all who have lost loved ones. “

The spokesperson praised the “collective national effort” and the “hard work” of frontline staff and volunteers and urged people to get vaccinated, saying “the pandemic is not over.”

Professor Andrew Hayward, who advises the government on Sage, said it was “absolutely tragic”.

After hearing the testimony of a woman who lost two loved ones during the pandemic, the academic from University College London told BBC Radio 4’s PM program: ‘It is absolutely tragic and to think it has been repeated so many times is horrible.

“I think we could have done better. I think some deaths are all the more tragic since many of them could have been avoided if we had acted earlier in wave one and wave two. “

Official figures showed an additional 146,390 people tested positive for Covid-19 in the past 24 hours, bringing the total from seven days to 1.2 million.

Separate figures released by the Office for National Statistics show that there are now 174,000 registered deaths in the UK where Covid-19 was mentioned on the death certificate.


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Proof of vax? Absolutely – Riverside Brookfield Landmark https://vorotynsk.com/2022/01/04/proof-of-vax-absolutely-riverside-brookfield-landmark/ Tue, 04 Jan 2022 22:00:07 +0000 https://vorotynsk.com/2022/01/04/proof-of-vax-absolutely-riverside-brookfield-landmark/ January 3rd, if you want to eat in a restaurant or drink in a bar in the suburb of Cook County, if you want to go to the movies and enjoy a bucket of popcorn, if you want to hit the gym and puff and puff throughout your workout, you will need to provide proof […]]]>

January 3rd, if you want to eat in a restaurant or drink in a bar in the suburb of Cook County, if you want to go to the movies and enjoy a bucket of popcorn, if you want to hit the gym and puff and puff throughout your workout, you will need to provide proof of COVID-19 vaccination.

For the most part, you will see the owners of these businesses, coming into close and prolonged contact with members of the public and putting them in close proximity to each other, happy to comply.

As Martin Lynch, owner of The Irish Times in Brookfield, told our food editor, Melissa Elsmo this week, “A vaccine requirement for staff and customers will only hasten our exit from this whole pandemic. “


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Stuart Dallas alongside Leeds United greatest after historic goal https://vorotynsk.com/2022/01/02/stuart-dallas-alongside-leeds-united-greatest-after-historic-goal/ Sun, 02 Jan 2022 20:00:00 +0000 https://vorotynsk.com/2022/01/02/stuart-dallas-alongside-leeds-united-greatest-after-historic-goal/ It was a memorable afternoon for Stuart Dallas, who scored in his 250th appearance for Leeds United to help his side to a 3-1 win over Burnley at Elland Road on Sunday. The Northern Irishman scored the Whites’ second goal, coming in from the edge of the box after Maxwel Cornet equalized for the Clarets […]]]>

It was a memorable afternoon for Stuart Dallas, who scored in his 250th appearance for Leeds United to help his side to a 3-1 win over Burnley at Elland Road on Sunday.

The Northern Irishman scored the Whites’ second goal, coming in from the edge of the box after Maxwel Cornet equalized for the Clarets just after half-time.

Jack Harrison and Daniel James scored the other goals as Leeds registered their first win in four matches and moved eight points away from the relegation zone heading into the second half of the season.

It was an impressive performance from Marcelo Bielsa’s side and Dallas embodied everything they did well, pressing from midfield and controlling the game when in possession.

He started the game promising and nearly opened the scoring in the 17th minute as he stepped into the penalty area and landed a low shot to the bottom corner, but Wayne Hennessey did well to clear the ball away.

Dallas had another chance halfway through the middle of the second half after hanging on to a long ball but couldn’t get a shot until Hennessey came in to close it.

However, the 30-year-old scored his goal when Mateusz Klich rolled the ball into the Dallas path and he touched before leading a wonderful finish past the Clarets keeper and into the corner of the net.

Meanwhile, Dallas has only become the sixth Leeds player to score in their 250th game for the club, joining perhaps the two greatest players to ever don a Leeds shirt during the achievement.

Billy Furness was the first to achieve this record, scoring a clash with Bolton Wanderers in 1937, before Welsh legend John Charles scored a goal against Leicester City in 1955.

Meanwhile, iconic Billy Bremner and Mick Jones are also on the roster and it’s safe to say Dallas is among the elite companies after what the previous five achieved in the Whites. Rod Wallace was the last player to achieve this when he scored against Birmingham City in 1998.

Wallace has been a vital part of the Leeds squad for seven seasons and Furness has scored 66 goals in 257 games for the club, while Charles is still the second-highest scorer in White history.

Bremner made more than 750 appearances for the West Yorkshire side during an illustrious 16-year spell in the 1960s and 1970s and Jones scored more than 100 goals during his time at the club.

Dallas, who played a pivotal role in promoting Whites to the Premier League and ninth place last season, could be vital in their hopes for a positive second half of the campaign.

Leeds will be next in action in the FA Cup third round next Sunday as they travel to West Ham United.


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Iconic Shanghai landmarks illuminated to mark the New Year https://vorotynsk.com/2022/01/01/iconic-shanghai-landmarks-illuminated-to-mark-the-new-year/ Sat, 01 Jan 2022 05:47:00 +0000 https://vorotynsk.com/2022/01/01/iconic-shanghai-landmarks-illuminated-to-mark-the-new-year/ Ti Gong The Shanghai Disney Resort rings in 2022 in Disney style with a special fireworks display. Shanghai, the city that never sleeps, lit up the night to welcome the New Year. The Shanghai Tower, the second tallest building in the world, enjoys an enviable position overlooking the city skyline, allowing people to experience the […]]]>

Ti Gong

The Shanghai Disney Resort rings in 2022 in Disney style with a special fireworks display.

Shanghai, the city that never sleeps, lit up the night to welcome the New Year.

The Shanghai Tower, the second tallest building in the world, enjoys an enviable position overlooking the city skyline, allowing people to experience the best of nighttime glamor from both banks of the Huangpu River.

Inside the building, all-new light shows debuted at SKY 632, a new art space on the 126th floor, where the world’s heaviest shock absorber, weighing 1,000 tons, is down to withstand typhoons.

Iconic Shanghai landmarks illuminated to mark the New Year

Jiang Xiaowei / SHINE

A spectacular light show debuts at the Shanghai Tower.

Colorful play of light illuminates the artistic installation, like a giant eye, just above the shock absorber, accompanied by holograms and sound effects. Each show is unique as the light and music change with the sway of the shock absorber, according to chief designer Sha Xiaolan.

The show officially opens to the public today. Access the official WeChat account of the Shanghai Tower (TopofShanghai) to purchase tickets, priced at 268 yuan (US $ 42) for an adult.

Iconic Shanghai landmarks illuminated to mark the New Year

Jiang Xiaowei / SHINE

Special holographic effects

Meanwhile, Shanghai Disney Resort rang in 2022 in Disney style with a special fireworks display.

The festive show, held on New Years Eve, featured spectacular fireworks displays, dazzling lights, stunning screenings and upbeat music.

Iconic Shanghai landmarks illuminated to mark the New Year

Jiang Xiaowei / SHINE

The light show is fascinating.

During the extravagance, fireworks lit the night sky with a giant “2022”. Visitors had the opportunity to receive surprise gifts upon arrival and were greeted by beloved Disney friends dressed in festive outfits.

The exclusive exclusive New Years Eve night show will be featured once again this evening.


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Friedman’s, a landmark of Petaluma, turns 75 https://vorotynsk.com/2021/12/30/friedmans-a-landmark-of-petaluma-turns-75/ Thu, 30 Dec 2021 13:18:16 +0000 https://vorotynsk.com/2021/12/30/friedmans-a-landmark-of-petaluma-turns-75/ In March 1946, residents of Santa Rosa, Joe and Benny Friedman, turned over their savings – $ 4,000 – to purchase the contents of Meyer Lerer’s Petaluma Junkyard and rent the property at 17 East Washington St., on the River and near the corner of what was then known as Main Street. And on April […]]]>

In March 1946, residents of Santa Rosa, Joe and Benny Friedman, turned over their savings – $ 4,000 – to purchase the contents of Meyer Lerer’s Petaluma Junkyard and rent the property at 17 East Washington St., on the River and near the corner of what was then known as Main Street.

And on April 1, the city of Petaluma issued a business license (at a cost of $ 3) to the new venture, Friedman Brothers. A third brother, Harry, would soon join the young company.

In “The Friedman’s Way”, a private book detailing the history of the company, Harry referred to Petaluma as “languid” at the time. You could cross Washington Street and stop in the middle to tie your shoe.

Lerer had said the brothers’ business was great but, as the book reports, day one sales totaled $ 1, and that’s only because there hasn’t been any change, Benny recalls. A sociable man with a sense of humor, Benny continued the story with, “Day two business has gone downhill. And on the third day a man come in to ask for change for a twenty dollar bill. We made him a partner.

However, the military’s demand for metal during WWII meant a shortage of raw materials after the war, and the hard-working brothers fared well. So much so, in fact, that 75 years later this scrap and salvage business, now known as Friedman’s Home Improvement, is a staple in the Sonoma County community and continues to thrive and grow.

In 1971, a new, modern branch of the store opened south of Santa Rosa. Five years later, the original East Washington Street store had become dilapidated, and inventory, headquarters, and staff moved to the new store. Harry, quoted in “The Friedman’s Way,” said: “It was a difficult decision. I cried when we left Petaluma, remembering all the good times, the hard work, and the wonderful friends and clients. They painted a sign and left it on the front window. “Moved to Santa Rosa,” he would say, “BUT WE WILL BE BACK. “

It took 38 years, but in 2014 the new Petaluma branch, now the corporate headquarters, opened in Deer Creek Village Mall on North McDowell Boulevard. In the years that followed, two more branches opened – in Ukiah and in Sonoma City.

It remains a family business, with Barry Friedman, 43, Benny’s grandson, now running the business. “I feel honored,” said Barry, “to lead this organization into the future.”

Barry said connecting with the community has always been a big part of the business.

“The way my grandfather and his brothers approached business was to treat people fairly, see what the community needed and do what met those needs, then give back to the community,” he said. -he declares.

When asked what has kept Friedman’s so strong for so long, Barry emphasized the company’s values: Lead, Connect, Grow, Serve and Care.

“It’s part of our daily work,” he said.

All new employees spend their first day in a company orientation, learning about the history and ethics of the company.

“I greet them, ask questions about them and ask why they chose Friedman’s.” It emphasizes to them the importance of people: “how you treat other members of your team and your customers”.

We see it as “the three circles,” he said: the team, the customers and the community. And the team is “the people who are committed to Friedman’s”. Even those who haven’t been around for a long time, “they want to be a part of something, and they do it because nothing happens without them. You don’t do it because you are asked to, but because you want to.

He started working in the store at the age of 8, “pushing carts and bagging for cashiers”. After college however, he wanted to make sure the company was the right fit for him. For a while he investigated being a cowboy in Montana and worked with a car racing team in North Carolina.

“But I was drawn to this business and in 2004 I came back and started over as a cashier from the beginning.” He rose through the ranks, he explained, to “keep his feet on the ground. I knew I would have opportunities, but I wanted to learn the trade, understand the pieces and the pieces.

In 2013, he became Chairman and Chief Executive Officer. “I like it: what we do, who we do it for and I like our place in the community. There is a lot of pride in knowing that we are a local company, offering great jobs and careers.

One of Friedman’s trademarks is its knowledgeable and helpful staff. In “The Friedman’s Way,” longtime general manager Ron Adams spoke about a time he showed Friedman’s to a big box store executive. “I walked… with him,” Adams said. “When we got to the cast iron stoves, he said to me, ‘We sell them too.’ I said, ‘No, you have them. We sell them. This is how I felt about Friedman’s… We have trained our employees to have an in-depth knowledge of our product lines and a real focus on customer needs.

Many locals are familiar with the company’s original slogan: “If we don’t have it, you don’t need it”. This, Barry said, was granted by a repeat customer in the early years. The man came from Willits because the business had become well known as a place to locate hard to find items. He once said, “If you don’t have it, I don’t need it.

He then gave permission to the brothers to use the slogan. Now, said Barry, it’s a relic of a time when things were hard to find. “It’s a good thing,” he added, to hear longtime county residents recall driving near this sign as children.

What about the future? “We are trying to create a more solid foundation for future growth,” Barry said. “Even though we’ve been around for a long time, our business has grown. Some of our processes needed strengthening and over the past few years we have focused on consolidating this foundation. We will only grow if we can ensure that we can maintain the culture and service that we expect – and that connection to our community.

“So, rhythmic and thoughtful growth,” he concluded. “We want to make sure we maintain our uniqueness, not just grow for the sake of growing. “


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Therapeutic Solutions International receives landmark patent for treatment of cancer and COVID-19 https://vorotynsk.com/2021/12/28/therapeutic-solutions-international-receives-landmark-patent-for-treatment-of-cancer-and-covid-19/ Tue, 28 Dec 2021 18:17:00 +0000 https://vorotynsk.com/2021/12/28/therapeutic-solutions-international-receives-landmark-patent-for-treatment-of-cancer-and-covid-19/ QuadraMune® The commercially available “nutraceutical checkpoint inhibitor” has been shown to target the immunosuppressive pathway of indolamine 2,3 deoxygenase. OCEANSIDE, California, December 28, 2021– (BUSINESS WIRE) – Therapeutic Solutions International today announced that it has received a Notice of Authorization from the United States Patent and Trademark Office for its patent application entitled “Nutraceuticals for […]]]>

QuadraMune® The commercially available “nutraceutical checkpoint inhibitor” has been shown to target the immunosuppressive pathway of indolamine 2,3 deoxygenase.

OCEANSIDE, California, December 28, 2021– (BUSINESS WIRE) – Therapeutic Solutions International today announced that it has received a Notice of Authorization from the United States Patent and Trademark Office for its patent application entitled “Nutraceuticals for Suppressing Indolamine 2,3 Deoxygenase ”.

To the Company’s knowledge, this is the first patent granted for a nutraceutical supplement to stimulate the immune system by blocking the immunosuppressive activities used by cancer and viruses in the IDO pathway. The supplement, called “QuadraMune®” is commercially available on the Company’s website and through Amazon.

Many drugs such as Optivo®, Yervoy® and Keytruda® have been approved by the FDA for the treatment of cancers by boosting immunity while blocking the mechanisms of immune inhibition. This class of drugs, called “checkpoint inhibitors,” represents a market of $ 15.2 billion per year.1.

“The indolamine 2,3 deoxygenase (IDO) pathway is considered to be one of the major immunological checkpoints on the basis that blocking small molecules from this pathway results in the immune destruction of tumors in animals.” said Dr Thomas Ichim, Board Member and co-inventor of the patent. “Unfortunately, previous approaches to suppress this pathway relied on toxic compounds that have not performed well in clinical trials, in part due to the inability to deliver sufficient doses without suggesting toxicity. excited about the possibility that QuadraMune®, a nutraceutical composition that is commercially available, may act as a potent immune booster targeting the IDO pathway without the drawbacks of other approaches. “

In 20132 then in 20183Dr. Ichim and colleagues have published regression of breast cancer by inhibiting the IDO pathway using an RNA interference approach. The current data and the granted patent represent years of fundamental scientific study into the relationship between IDO and the immune system.

“As a physician who sees firsthand the ravages of cancer and viruses, I am extremely excited about our ability to modulate critical immunological pathways using natural ingredients such as pterostilbene, thymoquinone, gallate d ‘epigallocatechin and sulforaphane,’ said Dr James Veltmeyer, Chief Physician of the Company and Co-inventor of the patent. “What is particularly important is that after our patents were filed, many independent universities validated the anti-COVID activity of the individual ingredients. These studies are summarized in our previous press release.4. “

“The acceptance of our data by the United States Patent Office upon granting the current patent is a major achievement for the company,” said Timothy Dixon, President and CEO and co-inventor of the patent. “The Company has filed numerous patent applications covering multiple nutraceuticals and uses, including; # 16/898472 titled “Nutraceuticals for reducing myeloid suppressing cells” and c) # 16/907335 titled “Treatment of SARS-CoV-2 with dendritic cells for innate and / or adaptive immunity”.

About Therapeutic Solutions International, Inc.

Therapeutic Solutions International focuses on immune modulation for the treatment of several specific diseases. The company’s website is www.therapeuticsolutionsint.com, and our public forum is https://board.therapeuticsolutionsint.com/

1 Global Checkpoint Inhibitors Market (2021 to 2030)

2 Silencing IDO in dendritic cells: A new approach to improve cancer immunotherapy in a mouse model of breast cancer – Zheng – 2013

3 A new cancer immunotherapy via the simultaneous mobilization of DCs and the silencing of the IDO gene targeted on DCs using an immunostimulating nanosystem – Zhang – 2018

4 Therapeutic Solutions International discusses claims of possible COVID-19 suppressive activity of QuadraMune ™ ingredients by independent universities after patent filing

See the source version on businesswire.com: https://www.businesswire.com/news/home/20211228005154/en/

Contacts

Timothy G. Dixon
ir@tsoimail.com


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Doctor Strange 2 Photo Set Reveals Destroyed MCU Monument https://vorotynsk.com/2021/12/26/doctor-strange-2-photo-set-reveals-destroyed-mcu-monument/ Sun, 26 Dec 2021 22:56:18 +0000 https://vorotynsk.com/2021/12/26/doctor-strange-2-photo-set-reveals-destroyed-mcu-monument/ A photo taken from Doctor Strange in the Multiverse of Madness reveals that the sequel will see the destruction of a major magical landmark. Photos of the set Doctor Strange in the Multiverse of Madness reveal the destruction of a major monument in the Marvel Cinematic Universe. On a photo shared on Instagram, the next […]]]>

A photo taken from Doctor Strange in the Multiverse of Madness reveals that the sequel will see the destruction of a major magical landmark.

Photos of the set Doctor Strange in the Multiverse of Madness reveal the destruction of a major monument in the Marvel Cinematic Universe.

On a photo shared on Instagram, the next one Doctor strange The sequel will see the destruction of New York’s Sanctum Sanctorum, the seat of Benedict Cumberbatch’s former wizard, Dr. Stephen Strange. It’s unclear what or who destroyed the large circular window in the Sanctorum, but it clearly caused significant damage.

RELATED: Spider-Man: No Way Home Introduces Doctor Strange 2 Trailer In An Unconventional Way

Doctor Strange in the Multiverse of Madness is currently the subject of “major reshoots,” which began filming in November with director Sam Raimi returning to direct additional material. He was joined by writer Michael Waldron, who served as editor-in-chief of Marve’s Loki Disney + series. Raimi took over as director from Scott Derrickson, who directed the first film and left the sequel in September 2020 due to creative differences. Cumberbatch, the star of the film, previously said that the covers only make the sequel “even better”.


In a separate interview, Cumberbatch said the takeovers were largely the result of logistical issues and restrictions caused by the coronavirus pandemic (COVID-19). “We’re in the midst of reshoots and we’re working incredibly hard to make a timeline work to realize the full potential of the film – pieces that we want to do better but also pieces that were just simply impossible to bring to light because of the logistics. , COVID, etc., ”he said.“ We were so delayed in production because of it. Fortunately, not too much during production. Although everything is just a little slower. “

RELATED: Doctor Strange 2’s MCU Cast Report Reportedly Includes Fantastic Four Member


The potential for new characters to appear in the sequel is vast, as Multiverse of Madness will continue to expand into the growing multiverse of the MCU. While it has been confirmed that the film will feature America Chavez / Miss America (played by Xochitl Gomez), a recent report also said that the covers will include even more cameos and character introductions than originally intended. Although the characters themselves have not been confirmed, sources report that the film will have “more fun with the multiverse” after the success of Spider-Man: No Path Home.

As for cameos, a new range of figurines for Doctor Strange in the Multiverse of Madness offered a first look at Rintrah’s possible introduction into the MCU, an alien minotaur who appeared in Marvel Comics as one of Doctor Strange’s apprentices. It has also been confirmed that Elizabeth Olsen will reprise her role as Wanda Maximoff / The Scarlet Witch, as the events of WandaVision will be directly linked to the following. Olsen wrapped the shoot of her Doctor strange resumed in September.


Doctor Strange in the Multiverse of Madness is scheduled to arrive in theaters on May 6, 2022.

KEEP READING: Doctor Strange Lead Character Is Rumored For Marvel’s She-Hulk

Source: Instagram

Spider-Man: No Way Home tops $ 1 billion at the box office


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